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Genetics and Karyotype Analysis

By Platform Administrator · Submitted Sep 30, 2026

Content Area
Science and Technology/Engineering
Grade
10

Students take on the role of a doctor or genetic counselor. Students are given a karyotype to identify chromosomal disorders in utero. Students research any abnormalities found. Students then write letters to inform fictional parents of their findings for their unborn son or daughter. The letter should explain what a karyotype is, the difference between a normal and abnormal karyotype, and what disease has been diagnosed. A successful result will be an accurately arranged karyotype and a proper diagnosis of the genetic disorder of the karyotype.

MA Standards

HS.LS.3.2
Make and defend a claim based on evidence that genetic variations (alleles) may result from (a) new genetic combinations via the processes of crossing over and random segregation of chromosomes during meiosis, (b) mutations that occur during replication, and/or (c) mutations caused by environmental factors. Recognize that mutations that occur in gametes can be passed to offspring. Clarification Statement: Examples of evidence of genetic variation can include the work of McClintock in crossing over of maize chromosomes and the development of cancer due to DNA replication errors and UV ray exposure. State Assessment Boundary: Specific phases of meiosis or identification of specific types of mutations are not expected in state assessment.
SEP.4
Analyzing and interpreting data
WCA.9-10.2.d
Use precise language and domain-specific vocabulary to manage the complexity of the topic and convey a style appropriate to the discipline and context as well as to the expertise of likely readers.

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